Cancer: a dysmethylation syndrome

Maurice Israël, Laurent Schwartz - Collection Sélection médecine sciences

115 pages, parution le 05/01/2006

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Résumé

In this book, the authors suggest that a "dysmethylation syndrome" disrupts essential regulations controlling cellular growth, metabolism and mitosis, and may then cause cancer. Dysmethylations (hyper or hypomethylations) affect not only the expression of genes controlling growth and mitosis, but also the activity of enzymes such as (PP2A) phosphatase, which is assembled after methylation, PP2A limits the action of trophic kinases activated by growth factors or by oncogenes.

In neurones, the syndrome associated to a poor methylation of the phosphatase and other substrates, leads to hyperphosphorylated proteins, as found in Alzheimer's disease. Cancer, Alzheimer's disease may possibly have, like Biermer's anemia, essential links with methylation processes.

L'auteur - Laurent Schwartz

Laurent Schwartz est médecin. Il est cancérologue de l'Assistance Publique des Hôpitaux de Paris (AP-HP) et a travaillé plus de vingt ans à l'École Polytechnique. Entouré d'une équipe de chercheurs, il oeuvre pour le bien des malades au développement de traitements novateurs et non toxiques du cancer.

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Sommaire

Introduction
Cancer as a disease of the genome
Cancer cannot be summarized as a disease of the genome
Major anti-cancer drugs are not cytotoxic
Cancer as a metabolic disease: back to Otto Warburg
Cytotoxic chemotherapy changes the metabolism
Glucose metabolism: controls that might be perturbed in tumors
Glycolysis, gluconeogenesis, in normal tissues and tumors: the malate-aspartate shuttle
The special metabolism of tumors: cause or consequence? Pyruvate kinase blockade, role of PP2A phosphatase
Hexokinase: the first enzyme of glycolysis, its control by oxidative mitochondrial metabolism
Phosphatase PP2A failure and mitosis
Histone status and gene transcription in normal and tumor cells
Do oncogenes prove the metabolic tumorigenic model?
Inflammation and cancer: urate or ascorbate protection
Chemotaxis or ancient hunger signals, involved in cancer and inflammation
Cell adhesion-proteolysis and the control of differentiation
Cytotoxic drugs that change either gene methylations,
or protein methylations, exemplified by PP2A phosphatase
Resistance to chemotherapy: metabolic cycles run amok
The metabolic disturbances caused by chemotherapy are carcinogenic
Conclusion
The dysmethylation hypothesis and cancer
References

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Caractéristiques techniques

	PAPIER
Éditeur(s)	John Libbey
Auteur(s)	Maurice Israël, Laurent Schwartz
Collection	Sélection médecine sciences
Parution	05/01/2006
Nb. de pages	115
Format	17 x 24,5
Couverture	Broché
Poids	260g
Intérieur	Quadri
EAN13	9782742005970
ISBN13	978-2-7420-0597-0